منابع مشابه
Halobetasol versus clobetasol: a study of potency.
Sir, Topical corticosteroids (TCS) are an integral part of dermatological therapeutics. The clinical effects of TCS depend on the structure of the molecule, the vehicle and the skin onto which it is applied.[1] Addition of a fluorine molecule at six and/ or nine positions enhances the potency of TCS. Halobetasol propionate has 6α flouro clobetasol 17-propionate as the active ingredient. Very oc...
متن کاملClobetasol down-regulates SLPI expression in U937 monocytoid cells.
In order to investigate how glucocorticoids affect the expression of secretory leukocyte peptidase inhibitor (SLPI), which is overexpressed in a variety of cancers, clobetasol was added to cell culture medium of U937 cells and the SLPI mRNA levels were examined. The in vitro effect of the treatment on SLPI expression was detected by reverse transcriptase-polymerase chain reaction. Clobetasol tr...
متن کاملCushing's syndrome and pituitary-adrenal suppression due to clobetasol propionate.
Widespread application of clobetasol propionate resulted in suppression of the hypothalamic pituitary axis in four patients. Three patients showed Cushigoid features and developed symptoms of adrenocortical insufficiency on withdrawal of clobetasol.
متن کاملUse of clobetasol in lacquer for plaque psoriasis treatment*
Clobetasol benefits to control psoriasis lesions are well defined, but there were not studies about its action when used in lacquer vehicle to control skin lesions. A double-blind study was conducted with 40 patients that utilized clobetasol 0.05% in one hemibody and just the vehicle in the other hemibody. Twenty of them used petrolatum as vehicle and the others used lacquer. An assessment was ...
متن کاملEffect on adrenal function of topically applied clobetasol propionate (Dermovate).
Thirty-nine patients (15 outpatients and 24 inpatients) with a variety of skin diseases affecting variable areas of the body surface were treated with clobetasol propionate ointment (Dermovate). Before and after treatment the adrenal response to an intramuscular injection of tetracosactrin was rested and additional 9 am plasma cortisol levels were measured at intervals during treatment. A satis...
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ژورنال
عنوان ژورنال: Reactions Weekly
سال: 2021
ISSN: ['1179-2051', '0114-9954']
DOI: https://doi.org/10.1007/s40278-021-95800-7